The mannose 6-phophate receptors (M6PR) are transmembrane glycoproteins that target lysosomal enzymes. There are two different M6PRs: the cation-independent M6PR which is 300 kDa, and the cation-dependent M6PR which is 46 kDa and requires divalent cations to efficiently recognize lysosomal hydrolases. Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein.
Novus Biologicals has recently added a new M6PR (cation independent) monoclonal antibody (NB300-514) and its 14 different conjugates to catalog. Sample size (unconjugated) is also available for your testing.
|M6PR (cation independent) Antibody
/IF analysis of M6PR (cation independent) (green) in cells
fixed with formaldehyde using NB300-514. F-Actin was stained with Phalloidin (red) and nuclei was stained with DAPI (blue).
You can also go to www.novusbio.com/productsearch/M6PR and check all M6PR products (cation dependent and cation independent) from Novus. Please contact us with any questions on these products. We look forward to providing quality tools for your research.